Low Dose Naltrexone

Low Dose Naltrexone (LDN) is a therapeutic, off-label use of the FDA-approved medication naltrexone, originally used in higher doses (50 mg) to treat opioid and alcohol addiction. In much smaller doses (typically 0.5–4.5 mg), LDN works in a completely different way: by gently modulating the immune system, reducing chronic inflammation, and supporting the body’s natural healing processes.

LDN is commonly used in functional and integrative medicine to help treat a wide variety of autoimmune, inflammatory, and chronic conditions, often with very few side effects.

How it Works

At low doses, LDN briefly blocks opioid receptors in the body, which leads to a rebound effect: the body increases production of endorphins (natural painkillers) and regulatory immune cells.

This helps to:

  • Calm overactive immune responses (seen in autoimmune diseases)

  • Reduce chronic inflammation

  • Modulate pain perception

  • Enhance mood and well-being

  • Support tissue repair and resilience

Benefits of LDN

  • Reduces chronic pain and inflammation

  • Helps regulate autoimmune activity

  • Supports mood, sleep, and energy

  • Enhances immune system balance

  • May slow progression of certain chronic diseases

  • Generally well-tolerated with minimal side effects

Frequently Asked Questions: NDA+

What conditions may benefit from LDN?

LDN is used as an adjunct therapy in conditions such as:

  • Fibromyalgia and chronic fatigue syndrome

  • Hashimoto’s thyroiditis

  • Multiple sclerosis (MS)

  • Rheumatoid arthritis

  • Psoriasis and eczema

  • Inflammatory bowel disease (Crohn’s, ulcerative colitis)

  • Long COVID and post-viral syndromes

  • Chronic pain syndromes or neuropathy

How is LDN taken?

LDN is usually prescribed as a compounded oral capsule or liquid, taken once daily—typically at night to support endorphin production during sleep.

How long does it take to see results?

Many patients begin to notice improvements in sleep, mood, or pain levels within 2–4 weeks, but full therapeutic effects may take 8–12 weeks or longer. Dosing is often started low and gradually increased.

Are there side effects?

LDN is typically very well tolerated. Some people experience:

  • Vivid dreams

  • Temporary sleep disturbances

  • Mild headaches or gastrointestinal upset (usually transient)

These effects often resolve as the body adjusts. Most people find LDN much easier to tolerate than conventional immunosuppressants or pain medications.

Can LDN be taken with other medications?

Yes, in most cases—but it should not be taken with opioid pain medications. Always consult your prescribing provider to review potential interactions.

Is LDN FDA approved?

Naltrexone is FDA-approved at higher doses, but LDN is an “off-label” use, which is legal and widely practiced in functional medicine. It is usually compounded by specialized pharmacies.

Is LDN Right for You?

If you’re dealing with chronic pain, fatigue, autoimmunity, or inflammation, Low Dose Naltrexone may be a safe and natural tool to support your long-term wellness. Book a consultation today to see if you’re a candidate for LDN therapy.